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Modeling and analysis of spatial trajectories of chromosomes in mitosis
Mathematical Biology| Speaker: | Christopher Miles, New York University |
| Related Webpage: | https://cims.nyu.edu/~cem9/ |
| Location: | Online (Zoom) |
| Start time: | Mon, Nov 23 2020, 2:10PM |
For cells to divide, they must undergo mitosis: the process of spatially organizing their copied DNA (chromosomes) to precise locations in the cell. Paradoxically, this procedure is carried out by stochastic components in the cell, yet manages to accomplish this task with astonishing speed and accuracy. Recent experimental advances have provided 3D spatial trajectories of every chromosome in a cell during mitosis. Can these trajectories tell us anything about the mechanisms driving them? Their noisiness and non-stationarity make applying common particle trajectory tools difficult. I will discuss our attempts at adapting classical data science ideas and modeling some emergent phenomenon from the data. This work is with Alex Mogilner at NYU and Alexey Khodjakov at the NY State Department of Health.
Seminars this quarter will be online on Zoom. Please see the math bio seminar series email list or contact the organizers for link and password.