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Mathematical models to study RNA-DNA hybrids
Mathematical Biology| Speaker: | Natasha Jonoska, University of South Florida |
| Location: | MSB 2112 |
| Start time: | Mon, Apr 28 2025, 4:10PM |
R-loops are co-transcriptional transient three-stranded nucleic acid formations that occur during transcription. They are RNA-DNA hybrids that form when the nascent RNA hybridizes to the template DNA, freeing the DNA coding strand. These events may affect double strand DNA break repairs as well as gene expression levels. With this presentation we describe a mathematical model for R-loops using a formal grammar approach. The model is trained on experimental single molecule R-loop foot-printing data. Although the model has no explicit topological information, the R-loop grammar model is able to predict R-loop formation on plasmids with varying starting topologies.
Also available on Zoom: https://ucdavis.zoom.us/j/98969645841